Detalles de la búsqueda
1.
Physiologically based pharmacokinetic modeling the reversible metabolism and tissue-specific partitioning of methylprednisolone and methylprednisone in rats.
Drug Metab Dispos
; 2024 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38653502
2.
Comparative Proteomic Analysis Identifies Key Metabolic Regulators of Gemcitabine Resistance in Pancreatic Cancer.
Mol Cell Proteomics
; 21(10): 100409, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36084875
3.
Pharmacokinetic/Pharmacodynamic Modeling of Dexamethasone Anti-Inflammatory and Immunomodulatory Effects in LPS-Challenged Rats: A Model for Cytokine Release Syndrome.
J Pharmacol Exp Ther
; 384(3): 455-472, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36631280
4.
Exploring the Pharmacokinetic Mysteries of the Liver: Application of Series Compartment Models of Hepatic Elimination.
Drug Metab Dispos
; 51(5): 618-628, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36732075
5.
Utility of Minimal Physiologically Based Pharmacokinetic Models for Assessing Fractional Distribution, Oral Absorption, and Series-Compartment Models of Hepatic Clearance.
Drug Metab Dispos
; 51(10): 1403-1418, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37460222
6.
Transitioning from Basic toward Systems Pharmacodynamic Models: Lessons from Corticosteroids.
Pharmacol Rev
; 72(2): 414-438, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32123034
7.
Pharmacokinetic/Pharmacodynamic Assessment of Selective Phosphodiesterase Inhibitors in a Mouse Model of Autoimmune Hepatitis.
J Pharmacol Exp Ther
; 381(2): 151-163, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35221290
8.
Assessing Liver-to-Plasma Partition Coefficients and In Silico Calculation Methods: When Does the Hepatic Model Matter in PBPK?
Drug Metab Dispos
; 2022 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36195337
9.
Consideration of Fractional Distribution Parameter fd in the Chen and Gross Method for Tissue-to-Plasma Partition Coefficients: Comparison of Several Methods.
Pharm Res
; 39(3): 463-479, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-35288804
10.
Pharmacodynamic model of slow reversible binding and its applications in pharmacokinetic/pharmacodynamic modeling: review and tutorial.
J Pharmacokinet Pharmacodyn
; 49(5): 493-510, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36040645
11.
Physiologically Based Pharmacokinetics of Lysosomotropic Chloroquine in Rat and Human.
J Pharmacol Exp Ther
; 376(2): 261-272, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33277347
12.
Synergistic Pharmacodynamic Effects of Gemcitabine and Fibroblast Growth Factor Receptor Inhibitors on Pancreatic Cancer Cell Cycle Kinetics and Proliferation.
J Pharmacol Exp Ther
; 377(3): 370-384, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33753538
13.
Mathematical modeling of mammalian circadian clocks affecting drug and disease responses.
J Pharmacokinet Pharmacodyn
; 48(3): 375-386, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33725238
14.
Population pharmacodynamic modeling of intramuscular and oral dexamethasone and betamethasone effects on six biomarkers with circadian complexities in Indian women.
J Pharmacokinet Pharmacodyn
; 48(3): 411-438, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33954911
15.
Pathway-level analysis of genome-wide circadian dynamics in diverse tissues in rat and mouse.
J Pharmacokinet Pharmacodyn
; 48(3): 361-374, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33768484
16.
Population pharmacokinetic modeling of intramuscular and oral dexamethasone and betamethasone in Indian women.
J Pharmacokinet Pharmacodyn
; 48(2): 261-272, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-33389521
17.
Across-species meta-analysis of dexamethasone pharmacokinetics utilizing allometric and scaling modeling approaches.
Biopharm Drug Dispos
; 42(5): 191-203, 2021 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-33638217
18.
Physiologically Based Pharmacokinetic Modeling Involving Nonlinear Plasma and Tissue Binding: Application to Prednisolone and Prednisone in Rats.
J Pharmacol Exp Ther
; 375(2): 385-396, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32883831
19.
Seeking Nonspecific Binding: Assessing the Reliability of Tissue Dilutions for Calculating Fraction Unbound.
Drug Metab Dispos
; 48(10): 894-902, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32759367
20.
Physiologically Based Pharmacokinetics of Dexamethasone in Rats.
Drug Metab Dispos
; 48(9): 811-818, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32601175